Total IgE levels and their relevance in the diagnosis of allergy among Malaysian population in the North-East Region of Peninsular Malaysia

Nor Azrini Azid, Mastura Md Sani, Anes Atiqah Zamry, Noor Suryani Mohd Ashari, Tina Hern-Tze Tan, Kah Keng Wong, Rohimah Mohamud

Abstract


Total immunoglobulin E (IgE) has been an indicator for early diagnosis of allergic diseases due the important role of IgE in the sensitization towards allergens. Although total IgE is a common diagnostic test that screens for possible allergic diseases, reports are still lacking on the profile of total IgE levels of allergic patients from the north-east region of Peninsular Malaysia. To investigate the association of total IgE levels with clinico-demographic parameters and whether increasing total IgE levels were associated with certain allergic manifestations in this study cohort. A local cohort of allergic patients (n=71) diagnosed in between 2009 and 2016 in Hospital Universiti Sains Malaysia (HUSM) were evaluated for the relevance of total IgE levels in allergy diagnosis. Our study did not demonstrate significant association between total IgE with age (p=0.75) or gender (p=0.65). However, we showed that elevated total IgE levels were associated with disease severity. Our data suggests that increasing total IgE levels beyond the conventional cutoff used to define abnormal IgE levels were more commonly associated with patients presenting allergic asthma and skin allergy manifestations. Total IgE level is a useful indicator for diagnosis of allergic diseases. Although total IgE level might not be sufficient to confirm the sensitization status of an individual, it may reflect the severity of the allergic disease suffered and it has a high correlation with positive sIgE values

Keywords


allergy, allergy diagnosis, Phadia reference values, total IgE

Full Text:

PDF

References


M. A. Kaliner, S. Del Giacco, “World Allergy Organization (WAO) White Book on Allergy: update 2013,” United State of America: WAO; 2013.p.23

M.V. White. (1990). The role of histamine in allergic diseases. J Allergy Clin Immun. 86(4), pp. 599-605.

Y. L. Tu, S. W. Chang, H. J. Tsai, L. C. Chen, W. I. Lee,. (2013). Total serum IgE in a population-based study of Asian children in Taiwan: Reference Value and Significance in the Diagnosis of Allergy. Plos One. 8(11).

A. H. Ahmad Al Obaidi, A. G. Mohamed Al Samarai, A. K. Yahya Al Samarai, J. M. Al Janabi. (2008). The predictive value of IgE as biomarker in asthma. J Asthma. 45(8), pp. 654-663.

D. Chung, K. T. Park, B. Yarlagadda, E. M. Davis, M. Platt. (2014). The significance of serum total immunoglobulin E for in vitro diagnosis of allergic rhinitis. Int Forum Allergy Rhinol. 4(1), pp. 56-60.

J. Vaneckova, J. Bukač. (2016). The severity of atopic dermatitis and the relation to the level of total IgE, onset of atopic dermatitis and family history about atopy. Food and Agricultural Immunology. 27(5), pp. 734-41.

G. J. Sturm, A. Heinemann, C. Schuster, M. Wiednig, A. Groselj-Strele, E. M. Sturm, et al. (2007). Influence of total IgE levels on the severity of sting reactions in Hymenoptera venom allergy. Allergy. 62(8), pp. 884-889.

K. D. Stone, C. Prussin, D. D. Metcalfe. (2010). IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immun. 125(2), pp. S73-S80.

K. C. Flint, K. B. Leung, B. N. Hudspith, J. Brostoff, F. L. Pearce, N. M. Johnson. (1985). Bronchoalveolar mast cells in extrinsic asthma: a mechanism for the initiation of antigen specific bronchoconstriction. Br Med J (Clin Res Ed). 291(6500), pp. 923-6.

S. Weidinger, C. Gieger, E. Rodriguez, H. Baurecht, M. Mempel, N. Klopp, et al. (2008). Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. PLoS Genet. 4(8), e1000166.

P. M. Salo, A. Calatroni, P. J. Gergen, J. A. Hoppin, M. L. Sever, R. Jaramillo, et al. (2011). Allergy-related outcomes in relation to serum IgE: results from the National Health and Nutrition Examination Survey 2005-2006. J Allergy Clin Immun. 127(5), pp. 1226-35. e7.

M. Simoni, P. Biavati, S. Baldacci, L. Carrozzi, M. Pedreschi, F. Di Pede, et al. (2001). The Po River Delta epidemiological survey: Reference values of total serum IgE levels in a normal population sample of North Italy (8-78 yrs). Eur J Epidemiol. 17(3), pp. 231-239.

A. Carosso, M. Bugiani, E. Migliore, J. M. Anto, R. DeMarco. (2007) Reference values of total serum IgE and their significance in the diagnosis of allergy in young European adults. International archives of allergy and immunology. 142(3), pp. 230-8.

C. I. Ezeamuzie, S. F. Al-Ali, A. Al-Dowaisan, M. Khan, Z. Hijazi, M. S. Thomson. (1999). Reference values of total serum IgE and their significance in the diagnosis of allergy among the young adult Kuwaiti population. Clin Exp Allergy. 29(3), pp. 375-81.

M. Kerkhof, A. Dubois, D. Postma, J. Schouten, J. Monchy. (2003). Role and interpretation of total serum IgE measurements in the diagnosis of allergic airway disease in adults. Allergy. 58(9), pp. 905-911.

D. Sinclair, S. Peters. (2004). The predictive value of total serum IgE for a positive allergen specific IgE result. J Clin Pathol. 57(9), pp. 956-9.

E. J. Kim, J. W. Kwon, Y. M. Lim, D. Yoon, J. H. Seo, W. S. Chang, et al. (2013). Assessment of Total/Specific IgE Levels Against 7 Inhalant Allergens in Children Aged 3 to 6 Years in Seoul, Korea. Allergy Asthma Immun. 5(3), pp. 162-9.

J. A. Al-Mughales. (2016) Diagnostic Utility of Total IgE in Foods, Inhalant, and Multiple Allergies in Saudi Arabia. J Immunol Res.

ThermoScientific. ImmunoCAP Total IgE: Quantifying the total cconcentration of IgE with ImmunoCAP Total IgE results in the evaluation of IgE-mediated allergy 2012 [cited 2017 21 march 2017]. Available from: http://www.phadia.com/en-GB/5/Products/ImmunoCAP-Assays/ImmunoCAP-Total-IgE/

C. C. Johnson, E. L. Peterson, D. R. Ownby. (1998). Gender differences in total and allergen-specific immunoglobulin E (IgE) concentrations in a population-based cohort from birth to age four years. American journal of epidemiology. 147(12), pp. 1145-52.

N. Ballardini, C. Nilsson, M. Nilsson, G. Lilja. (2006). ImmunoCAPTM Phadiatop® Infant – a new blood test for detecting IgE sensitisation in children at 2 years of age. Allergy. 61(3), pp. 337-43.

O. Zetterstöm, S. Johansson. (1981). IgE concentrations measured by PRIST® in serum of healthy adults and in patients with respiratory allergy. Allergy. 36(8), pp. 537-47.

T. A. P. D. Couto, N. Falsarella, C. D. B. de Mattos, L. C. de Mattos. (2014). Total IgE plasma levels vary according to gender and age in Brazilian patients with allergic rhinitis. Clinics. 69(11), pp. 740-4.

L. P. Boulet, H. Turcotte, C. Laprise, C. Lavertu, P. M. BEDARD, A. Lavoie, et al. (1997). Comparative degree and type of sensitization to common indoor and outdoor allergens in subjects with allergic rhinitis and/or asthma. Clinical & Experimental Allergy. 27(1), pp. 52-9.

T. M. Huurre, H. M. Aro, J. J. Jaakkola. (2004). Incidence and prevalence of asthma and allergic rhinitis: a cohort study of Finnish adolescents. Journal of Asthma. 41(3), pp. 311-317.

M. De Amici, G. Ciprandi. (2013). The Age Impact on Serum Total and Allergen-Specific IgE. Allergy, asthma & immunology research. 5(3), pp. 170-4.

J. Liebhart, R. Dobek, J. Małolepszy, B. Wojtyniak, K. Pisiewicz, T. Płusa, et al. (2013). The Prevalence of Allergic Diseases in Poland-the Results of the PMSEAD Study in Relation to Gender Differences. Advances in clinical and experimental medicine: official organ Wroclaw Medical University. 23(5), pp. 757-62.

A. P. Ligeiro de Oliveira, R. M. Oliveira-Filho, Z. L. da Silva, u. cia, P. Borelli, W. Tavares de Lima. (2003). Regulation of allergic lung inflammation in rats: interaction between estradiol and corticosterone. Neuroimmunomodulation. 11(1), pp. 20-7.

A. Dor-Wojnarowska, J. Liebhart, J. Miecielica, M. Rabski, A. Fal, B. Samoliński, et al. (2016). The Impact of Sex and Age on the Prevalence of Clinically Relevant Sensitization and Asymptomatic Sensitization in the General Population. Archivum Immunologiae et Therapiae Experimentalis. 1-9.

Amarasekera M. (2011). Immunoglobulin E in health and disease. Asia Pacific Allergy. 1(1), pp. 12-5.

J. Sheldon, L. Miller. (2014). Allergy Diagnosis Reference Guide. Clin Biochem. pp. 1-10.

M. Pino-Yanes, C. R. Gignoux, J. M. Galanter, A. M. Levin, C. D. Campbell, Eng C, et al. (2015). Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. J Allergy Clin Immun. 135(6), pp. 1502-10.

C. E. Brightling. (2011). Eosinophils, bronchitis and asthma: Pathogenesis of cough and airflow obstruction. Pulmonary pharmacology & therapeutics. 24(3), pp. 324-7.

Q. Hamid, M. K. Tulic, M. C. Liu, R. Moqbel. (2003). Inflammatory cells in asthma: Mechanisms and implications for therapy. Journal of Allergy and Clinical Immunology. 111(1), S5-S17.

M. A. Faber, M. Pascal, O. El Kharbouchi, V. Sabato, M. M. Hagendorens, I. I. Decuyper, et al. (2016). Shellfish allergens: tropomyosin and beyond. Allergy.

M. Giuffrida, D. Villalta, G. Mistrello, S. Amato, R. Asero. (2014). Shrimp allergy beyond Tropomyosin in Italy: clinical relevance of Arginine Kinase, Sarcoplasmic calcium binding protein and Hemocyanin. European annals of allergy and clinical immunology. 46(5), pp. 172-7.

R. H. Shafique, P. B. Klimov, M. Inam, F. R. Chaudhary, B. M. OConnor. (2014). Group 1 allergen genes in two species of house dust mites, Dermatophagoides farinae and D. pteronyssinus (Acari: Pyroglyphidae): direct sequencing, characterization and polymorphism. PloS one. 9(12), pp. e114636




Copyright (c) 2019 Journal of Biomedical and Clinical Sciences (JBCS)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Flag Counter           

                     

                                              Copyright © 2016 AMDI Publisher, Universiti Sains Malaysia.
Disclaimer : This website has been updated to the best of our knowledge to be accurate. However, Universiti Sains Malaysia shall not be liable for any loss or damage caused by the usage of any information obtained from this web site.
                                            Best viewed: Mozilla Firefox 4.0 & Google Chrome at 1024 × 768 resolution.