Primary Small Bowel Neurofibroma Induced Intussusception Complicated with Small Bowel Obstruction and Perforation: A Case Report

Muhamad Zabidi Ahmad


Neurofibromatosis (NF) is a genetic neurological disorder which can lead to abnormal tumour suppression. Neurofibromatosis associated neurological tumour is usually benign in nature, only occasionally can become malignant. Gastrointestinal involvement is reported to be infrequent with only up to 25% of patients with neurofibromatosis showing involvement. Solitary gastrointestinal neurofibroma is very rare, with most cases involving the stomach or small bowel. We report here a case of solitary small intestinal neurofibroma with no other associated systemic signs, causing intussusception and intestinal obstruction.


Neurofibromatosis, gastrointestinal neurofibroma, intussusception, intestinal obstruction, small intestine

Full Text:



Patel NB, Stacy GS. Musculoskeletal manifestations of neurofibromatosis type 1. Am J Roentgenol. 2012;

Chan JW. Neuro-ophthalmic features of the neurocutaneous syndromes. International Ophthalmology Clinics. 2012.

Landi A, Dugoni DE, Marotta N, Mancarella C, Delfini R. Spinal schwannomatosis in the absence of neurofibromatosis: A very rare condition. Int J Surg Case Rep. 2011;

Ferner RE, Gutmann DH. Neurofibromatosis type 1 (NF1): Diagnosis and management. In: Handbook of Clinical Neurology. 2013.

Garrouche N, Ben Abdallah A, Arifa N, Hasni I, Ben Cheikh Y, Ben Farhat W, et al. Spectrum of gastrointestinal lesions of neurofibromatosis type 1: a pictorial review. Insights into Imaging.

Hristova L, Placé V, Nemeth J, Boudiaf M, Laurent V, Soyer P. Small bowel tumors: Spectrum of findings on 64-section CT enteroclysis with pathologic correlation. Clin Imaging. 2012;

Chelimilla H, Chandrala CK, Niazi M, Kumbum K. Incidental finding of isolated colonic neurofibroma. Case Rep Gastroenterol. 2013;

Agaimy A, Vassos N, Croner RS. Gastrointestinal manifestations of neurofibromatosis type 1 (Recklinghausen’s disease): Clinicopathological spectrum with pathogenetic considerations. International Journal of Clinical and Experimental Pathology. 2012.

Di Saverio S, Tugnoli G, Ansaloni L, Catena F, Biscardi A, Jovine E, et al. Concomitant intestinal obstruction: a misleading diagnostic pitfall. BMJ Case Rep. 2010;

Begos DG, Sandor A, Modlin IM. The diagnosis and management of adult intussusception. Am J Surg. 1997;

Shonnard KM, Jelinek JS, Benedikt RA, Kransdorf MJ. Ct and mr of neurofibromatosis of the bladder. J Comput Assist Tomogr. 1992;

Levy AD, Patel N, Dow N, Abbott RM, Miettinen M, Sobin LH. Abdominal neoplasms in patients with neurofibromatosis type 1: Radiologic-pathologic correlation. Radiographics. 2005;

Bhargava R, Parham DM, Lasater OE, Chari RS, Chen G, Fletcher BD. MR imaging differentiation of benign and malignant peripheral nerve sheath tumors: Use of the target sign. Pediatr Radiol. 1997;

Cosgrove JM, Fischer MG. Gastrointestinal neurofibroma in a patient with von Recklinghausen’s disease. Surgery. 1988;

Copyright (c) 2020 Journal of Biomedical and Clinical Sciences (JBCS)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Journal of Biomedical and Clinical Sciences (JBCS) publishes original research articles, short review, short communication, case reports, quiz and letter to editor that covering the areas of fundamental aspects of biomedical and clinical sciences, from pre-clinical towards translational research and their applications in medicine, dentistry and healthcare management. JBCS aims to provide a platform for basic science and clinical researchers to communicate and share their research findings to the advancement of technologies in biomedical and clinical sciences by providing maximum access to scholarly communication.

Flag Counter           


                                              Copyright © 2016 AMDI Publisher, Universiti Sains Malaysia.
Disclaimer : This website has been updated to the best of our knowledge to be accurate. However, Universiti Sains Malaysia shall not be liable for any loss or damage caused by the usage of any information obtained from this web site.
                                            Best viewed: Mozilla Firefox 4.0 & Google Chrome at 1024 × 768 resolution.