Serum Level of Soluble Receptor for Advanced Glycation End Products in Acute Coronary Syndrome and Chronic Stable Angina Patients

Fatin Najiah Mohd Idrus, Siew Wai Fong, Chee Hock Hoe, Zurkurnai Yusof, Get Bee Yvonne-Tee


Acute coronary syndrome (ACS) and chronic stable angina (CSA) have different pathophysiological features and prognoses. Hence, a biomarker that can discriminate between ACS and CSA is crucial. Soluble receptor for advanced glycation end product (sRAGE) involved in vascular inflammation shows potential as the emerging diagnostic marker of ACS. Thus, this research examined the difference in serum level of sRAGE in ACS and CSA patients and investigated the association between sRAGE and plaque instability biomarkers like placental growth factor (PIGF). The serum levels of sRAGE and plaque instability biomarkers were measured from 13 ACS [47 years (26)] and 19 CSA patients [51 years (26)] using enzyme-linked immunoassay. The association between serum level of sRAGE and plaque instability biomarkers was determined by a correlation study. Serum level of sRAGE and PIGF were significantly higher in ACS [sRAGE: 3541 pg/mL (2153.8 pg/mL), p<0.000], [PIGF: 51.91 (31.94) pg/mL, p=0.001] compared to CSA patients [sRAGE: 1268 (1510) pg/mL], [PIGF: 17.28 (22.41) pg/mL]. Binomial logistic regression analysis revealed sRAGE and PIGF as possible predictors of ACS, p<0.05. The serum level of sRAGE was higher in ACS patients and could be the potential dual-biomarker with PIGF in cardiovascular disease (CVD) patients.


Acute coronary syndrome, biomarker, cardiovascular disease, chronic stable angina, PIGF, sRAGE

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