A Cost-Effective in-Silico Approach for Identification of MicroRNAs (MiRNAs) Involved in Cellular Senescence Pathwa

Yaashini Rajasegaran, Adam Azlan, Narazah Mohd Yusoff, Emmanuel Jairaj Moses


Accumulating evidences have shown that miRNA dysregulation occurs in the majority of human malignancies. This study aims to identify miRNAs that are involved in the cellular senescence pathway through in-silico approach. Two different bioinformatics approaches utilizing four bioinformatics software were used to identify overlapping miRNAs: Approach 1 and Approach 2. We found that the use of different bioinformatics approaches produces two different sets of results. These results imply that the use of different bioinformatics approaches is not only cost-effective but also produces more thorough and robust results that act as a preliminary screening which can be very useful for downstream applications.


miRNA dysregulation, cost-effective

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Journal of Biomedical and Clinical Sciences (JBCS) publishes original research articles, short review, short communication, case reports, quiz and letter to editor that covering the areas of fundamental aspects of biomedical and clinical sciences, from pre-clinical towards translational research and their applications in medicine, dentistry and healthcare management. JBCS aims to provide a platform for basic science and clinical researchers to communicate and share their research findings to the advancement of technologies in biomedical and clinical sciences by providing maximum access to scholarly communication.

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