Evaluation of the Performance of Automated Haematology Analyser Dymind DH73 Compared to Sysmex XN 1000 System

Zefarina Zulkafli, noor haslina mohd noor

Abstract


Many types of automated haematology analysers are available for the used in clinical laboratories. It is reasonable to assume that a newly acquired piece of diagnostic equipment would run as intended, as manufacturers perform their own validation testing to prove intended use prior to launching a product in the market.  Thorough validation testing on all new haematology analysers must be performed to ensure patient safety.  This study was carried out to validate Dymind DH73, the automated haematology analysers in the Hospital Universiti Sains Malaysia setting.  Blood samples send for complete blood count were selected randomly (n = 40) from healthy subjects and those who have different blood disorders. Blood specimens and quality control materials were analysed on the Dymind DH73 to evaluate precision, carry over and linearity. For correlation, we used the Sysmex XN-1000 as the comparative method. The study showed very good correlation (R > 0.9) between Dymind DH73 and Sysmex, XN-1000 in the parameters such as white blood cell, red blood cell, hemoglobin, platelet, nucleated rbc, neutrophil, lymphocyte, monocyte, eosinophil, and low correlation for basophil. In conclusion, the Dymind DH73 displayed a satisfactory performance with respect to precision, linearity and carry over. The performance of the Dymind DH73 analyser was good and compared favorably with the Sysmex XN-1000.


Keywords


Automated haematology analysers; correlation; Dymind DH73; haematological parameter; Sysmex XN-1000

Full Text:

PDF

References


S.O. Ike, T. Nubila, E.O Ukaejiofo, I.N. Nubila, E.N. Shu, I. Ezema (2010, April). Comparison of haematological parameters determined by the Sysmex KX – 2IN automated haematology analyzer and the manual counts. BMC Clinical Pathology [Online]. 10(1). Available: https://pubmed.ncbi.nlm.nih.gov/20416068/

M. Velizarova, T. Yacheva, M. Genova, D. Svinorov (2021, September). Evaluation of automated hematology analyzer DYMIND DH76 compared to SYSMEX XN 1000 system. J Med Biochem [Online] 40(4):367-377. Available: https://pubmed.ncbi.nlm.nih.gov/34616226/

D. Dave, A.N. Pandya (2014, March). Comparative Study of Four Hematology Analyzers. J Evol Med Dent Sci [Online] 3(12):3107-3113. Available: http://dx.doi.org/10.14260/jemds/2014/2251

R.K. Bhola, C. Fudaly, S. Rastogi (2024, April). A Comparative Evaluation of Performance of Sysmex XN 3000 and Horiba Yumizen H2500 Automated Complete Blood Count Analysers. Indian J Hematol Blood Transfus [Online] 40(2):303-314. Available: https://pubmed.ncbi.nl,.nih.gov/38708164/

P. Pusparini, A. Alvina (2022, September). Performance Comparison of Dymind DH-76 and Sysmex Xn-1000 Automated Hematology Analyzers. Indones J Clin Pathol Med Lab [Online] 257-262. Available: https://doi.org/10.24293/ijcpml.v28i3.1907.

M. Bruegel, D. Nagel, M. Funk, P Fuhrmann, J. Zander, D. Teupser (2015, January). Comparison of five automated hematology analyzers in a university hospital setting: Abbott Cell-Dyn Sapphire, Beckman Coulter DxH 800, Siemens Advia 2120i, Sysmex XE-5000, and Sysmex XN-2000. Clin Chem Lab Med [Online] 53(7):1057-71. Available: https://doi.org/10.1515/cclm-2014-0945

E. Schapkaitz, S. Raburabu (2018, March). Performance evaluation of the new measurement channels on the automated Sysmex XN-9000 hematology analyzer. Clin Biochem [Online] 53:132-138. Available: https://doi.org/10.1016/j.clinbiochem.2018.01.014

C. Briggs, N. Culp, B. Davis, G. d’Onofrio, G. Zini, S.J. Machin (2014, March) ICSH guidelines for the evaluation of blood cell analysers including those used for differential leucocyte and reticulocyte counting. Int J Hematol [Online] 36(6):613-27. Available: https://doi.org/10.1111/ijlh.12201

Products & Solutions, Dymind Biotechnology Co., Ltd. Shenzhen, China. [Online]. Available: https://www.dymind.com/en-US/products_and_solutions

S. Incir, K.E. Palaoglu. (2020, November). Evaluation of the performance of Sysmex XN-3100 automated hematology analyzer regarding the Sysmex XE-2100 and microscopic examination. Turk J Biochem. [Online]. pp. 29-37. Available: https://doi.org/10.1515/tjb-2020-0004

XN-1000 / 2000 XN-Series Automated Haematology Analysers Shaping Haematology, Sysmex Corporation, Kobe, Japan. [Online]. Available: https://www.sysmex-ap.com/wp-content/uploads/2020/08/XN-1000_2000-Brochure.pdf

S.S. Kaplan, K. Johnson, N. Wolfe, W. Brown, M. Keeny, L. Gray-Statchuk, et al. (2004, July) Performance characteristics of the Coulter LH 500 hematology analyzer. Lab Hematol. [Online] 10(2):76-87. Available: https://pubmed.ncbi.nlm.nih.gov/15224763/




Copyright (c) 2024 Journal of Biomedical and Clinical Sciences (JBCS)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Flag Counter           

                     

                                              Copyright © 2016 AMDI Publisher, Universiti Sains Malaysia.
Disclaimer : This website has been updated to the best of our knowledge to be accurate. However, Universiti Sains Malaysia shall not be liable for any loss or damage caused by the usage of any information obtained from this web site.
                                            Best viewed: Mozilla Firefox 4.0 & Google Chrome at 1024 × 768 resolution.