Microbial Profile of Culture-Proven Cases of Endophthalmitis in Hospital Universiti Sains Malaysia: A 7-year Retrospective Study

Norhayaty Samsudin, Sangeetha Tharmathurai, Evelyn Li Min Tai, Wan Hazabbah Wan Hitam, Zaidah Abdul Rahman, Azhany Yaakub

Abstract


Infectious endophthalmitis is a devastating and potentially sight-threatening condition. The objective is to analyse the microbiological profile and visual outcome of culture positive endophthalmitis seen in Hospital Universiti Sains Malaysia. All patients with endophthalmitis admitted to Hospital Universiti Sains Malaysia over a 7-year period from January 2007 until December 2013 were recruited into this study. Retrospective review of medical and microbiology records was conducted among patients clinically diagnosed with endophthalmitis in Hospital Universiti Sains Malaysia from January 2007 until December 2013. Sixteen patients were admitted with endophthalmitis during this study period. Seven (43%) were culture-positive, in which five (71%) cases were from vitreous culture and two (29%) from blood specimens. The mean age for culture positive patients of presentation was 44 years. The most common bacterial isolate was Pseudomonas spp., while the most common fungus was Candida spp. Other organisms isolated were Fusarium sp., Aspergillus sp., Staphylococcus sp. and Enterococcus sp. The risk factors for culture-positive cases were ocular trauma, corneal keratitis, ocular chemical injury, severe urinary tract infection and retropharyngeal abscess. Only three of the affected eyes could be salvaged. The final visual acuity was poor in all the culture-positive eyes. Two cases underwent evisceration while one case underwent enucleation. As a conclusion, Culture-positive endophthalmitis in this study were mainly attributed to Pseudomonas spp. and Candida spp. The visual outcome of culture-positive endophthalmitis was poor.

Keywords


endogenous endophthalmitis, exogenous endophthalmitis, culture positive, pseudomonas sp., candida sp.

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References


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